central effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks

oxyntomodulin (oxm), a proglucagon-derived peptide, is a well known anorexigenic peptide found inthe gut and brain of mammals. the present study was carried out to investigate the central effect of oxm onfood intake in non-fasted and fasted ross broiler chicks. at four weeks of age, a guide cannula wasstereotaxically implanted into the right lateral ventricle of each bird. two experiments were conducted onfree-feeding (non-fasted) and 6-h fasted broilers. in each experiment, eight birds were used in a replicated 4 × 4 latin square design. the birds were given an intracerebroventricular (icv) injection of different doses of mammalian oxm. intracerebroventricular injection of oxm at doses of 1.5, 3 and 6 nmol significantly(p